1-cyclopropyl-4-{4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine BAY87-2243
BAY 87-2243
CAS: 1227158-85-1
Molecular Formula: C26H26F3N7O2
1-cyclopropyl-4-{4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine BAY87-2243 - Names and Identifiers
1-cyclopropyl-4-{4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine BAY87-2243 - Physico-chemical Properties
| Molecular Formula | C26H26F3N7O2 |
| Molar Mass | 525.53 |
| Density | 1.47±0.1 g/cm3(Predicted) |
| Boling Point | 677.7±65.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| Appearance | solid |
| Color | White |
| pKa | 8.43±0.27(Predicted) |
| Storage Condition | RT |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| In vitro study | BAY87-2243 HIF-1 inhibition of reporter gene activity and CA9 protein expression, IC50 0.7 nM and 2 nM, respectively. In hypoxic lung cancer H460 cells, BAY 87-2243 inhibits HIF target gene expression and inhibits HIF-1α protein accumulation. Under glucose depletion, BAY 87-2243 inhibits cell proliferation by interfering with mitochondrial function. BAY87-2243 inhibited reporter gene activity and CA9 protein expression by HIF-1 with IC50 of 0.7 nM and 2 nM, respectively. In hypoxic lung cancer H460 cells, BAY 87-2243 inhibits HIF target gene expression and inhibits HIF-1α protein accumulation. Under glucose depletion, BAY 87-2243 inhibits cell proliferation by interfering with mitochondrial function. |
| In vivo study | In the H460 xenograft mouse model, BAY87-2243(4 mg/kg P. O.) reduced tumor weight, HIF-1α protein, and HIF-1 target gene expression levels. In the H460 xenograft mouse model, BAY87-2243(4 mg/kg P. O.) reduced tumor weight, HIF-1α protein, and HIF-1 target gene expression levels. |
1-cyclopropyl-4-{4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine BAY87-2243 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.903 ml | 9.514 ml | 19.029 ml |
| 5 mM | 0.381 ml | 1.903 ml | 3.806 ml |
| 10 mM | 0.19 ml | 0.951 ml | 1.903 ml |
| 5 mM | 0.038 ml | 0.19 ml | 0.381 ml |
Last Update：2024-01-02 23:10:35
1-cyclopropyl-4-{4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine BAY87-2243 - Introduction
BAY 87-2243 is a chemical substance whose characteristics include the following:
1. Properties: BAY 87-2243 is an organic compound with the chemical name of (2-methoxyethyl)-(5-[(2-fluorophenyl) amino] thiazolyl) amine. Its molecular formula is C12H15FN4OS and its molecular weight is 284.34g/mol.
2. Use: BAY 87-2243 is widely used in the field of cancer treatment research. As a new drug candidate, it exerts anti-tumor activity by inhibiting the growth and spread of tumor cells. In addition, BAY 87-2243 is also used to study the treatment of lung cancer and colorectal cancer.
3. Preparation method: there may be many specific methods for preparing BAY 87-2243, but there is no public standard synthesis route at present. In general, it can be synthesized by organic synthetic chemical reactions, and the relevant compounds need to be appropriately activated and functionalized.
4. Safety information: the safety and toxic effects of BAY 87-2243 have not been fully evaluated and confirmed. As a LABORATORY CHEMICAL, use should be strictly adhere to the relevant safety procedures, including wearing appropriate personal protective equipment, avoid direct contact with skin and eyes. In addition, avoid contact with oxidants and flammable substances during storage, and maintain a dry and well-ventilated environment. For specific safety information and toxicity data, it is recommended to consult a reliable safety data sheet or a relevant professional.
1. Properties: BAY 87-2243 is an organic compound with the chemical name of (2-methoxyethyl)-(5-[(2-fluorophenyl) amino] thiazolyl) amine. Its molecular formula is C12H15FN4OS and its molecular weight is 284.34g/mol.
2. Use: BAY 87-2243 is widely used in the field of cancer treatment research. As a new drug candidate, it exerts anti-tumor activity by inhibiting the growth and spread of tumor cells. In addition, BAY 87-2243 is also used to study the treatment of lung cancer and colorectal cancer.
3. Preparation method: there may be many specific methods for preparing BAY 87-2243, but there is no public standard synthesis route at present. In general, it can be synthesized by organic synthetic chemical reactions, and the relevant compounds need to be appropriately activated and functionalized.
4. Safety information: the safety and toxic effects of BAY 87-2243 have not been fully evaluated and confirmed. As a LABORATORY CHEMICAL, use should be strictly adhere to the relevant safety procedures, including wearing appropriate personal protective equipment, avoid direct contact with skin and eyes. In addition, avoid contact with oxidants and flammable substances during storage, and maintain a dry and well-ventilated environment. For specific safety information and toxicity data, it is recommended to consult a reliable safety data sheet or a relevant professional.
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: BAY 87-2243 Visit Supplier Webpage Request for quotationCAS: 1227158-85-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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